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Article

The Emerging Role of the FGF/FGFR Pathway in Gastrointestinal Stromal Tumor.

International journal of molecular sciences - 7 May 2020

Astolfi Annalisa, Pantaleo Maria Abbondanza, Indio Valentina, Urbini Milena, Nannini Margherita

Abstract excerpt

Gastrointestinal stromal tumors (GIST) are rare neoplasms of mesenchymal origin arising in the gastrointestinal tract. The vast majority are characterized by mutually exclusive activating mutations in KIT or Platelet-derived growth factor alpha (PDGFRA) receptors, or less frequently by succinate dehydrogenase complex (SDH) or NF1 inactivation, with very rare cases harboring mutant BRAF or RAS alleles....

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Identifiers

PMID: 32392832
DOI: 10.3390/ijms21093313
PMCID: PMC7246647

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