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Article

Molecular pathogenesis of multiple gastrointestinal stromal tumors in NF1 patients

6 Feb 2006

Abstract excerpt

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. KIT and PDGFRA activating mutations are the oncogenic mechanisms in most sporadic GISTs. In addition to sporadic occurrences, GISTs are increasingly being recognized in association with neurofibromatosis type 1 (NF1), yet the underlying pathogenic mechanism remains elusive. To gain an insight into the...

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PMID: 16461335
DOI: 10.1093/hmg/ddl016

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