Genomic stratification by expression of HLA-DRB4 alleles identifies differential innate and adaptive immune transcriptional patterns - A strategy to detect predictors of methotrexate response in early rheumatoid arthritis.

doi:10.1016/j.clim.2016.08.013

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Article

Genomic stratification by expression of HLA-DRB4 alleles identifies differential innate and adaptive immune transcriptional patterns - A strategy to detect predictors of methotrexate response in early rheumatoid arthritis.

Clinical immunology (Orlando, Fla.) - 1 Oct 2016

Stuhlmüller Bruno, Mans Karsten, Tandon Neeraj, Bonin Marc O, Smiljanovic Biljana, Sörensen Till A, Schendel Pascal, Martus Peter, Listing Joachim, Detert Jacqueline, Backhaus Marina, Neumann Thomas, Winchester Robert J, Burmester Gerd-R, Häupl Thomas

Abstract excerpt

Effective drug selection is the current challenge in rheumatoid arthritis (RA). Treatment failure may follow different pathomechanisms and therefore require investigation of molecularly defined subgroups. In this exploratory study, whole blood transcriptomes of 68 treatment-naïve early RA patients were analyzed before initiating MTX. Subgroups were defined by serologic and genetic markers. Response related...

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PMID: 27570220
DOI: 10.1016/j.clim.2016.08.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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