Article
HLA-DRB1 Shared Epitope Alleles and Disease Activity Are Correlated with Reduced T Cell Receptor Repertoire Diversity in CD4+ T Cells in Rheumatoid Arthritis.
The Journal of rheumatology - 1 Jul 2018
Sakurai Keiichi, Ishigaki Kazuyoshi, Shoda Hirofumi, Nagafuchi Yasuo, Tsuchida Yumi, Sumitomo Shuji, Kanda Hiroko, Suzuki Akari, Kochi Yuta, Yamamoto Kazuhiko, Fujio Keishi
Abstract excerpt
OBJECTIVE: Shared epitope (SE) alleles are the most significant genetic susceptibility locus in rheumatoid arthritis (RA); however, their target populations in CD4+ T cells are not well elucidated. We analyzed the association between SE alleles and the T cell receptor (TCR) repertoire diversity of naive and memory CD4+ T cells using next-generation sequencing (NGS). METHODS: The TCR beta chains in naive and...
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