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Discovery and Characterization of the Fully Decorated Nocardiosis-Associated Polyketide Natural Product

31 Jan 2024

Abstract excerpt

The genomes of 40 strains of Nocardia, most of which were associated with life-threatening human infections, encode a highly conserved assembly line polyketide synthase designated as the NOCAP (NOCardiosis-Associated Polyketide) synthase, whose product structure has been previously described. Here we report the structure and inferred biosynthetic pathway of the fully decorated glycolipid natural product. Its...

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PMID: 38295028
DOI: 10.1021/jacs.3c13670

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