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Article

Novel genome-wide associations for effort valuation and psychopathology in children and adults.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jun 2024

Nguyen Nicholas H, Mazza T Mitchell, Hess Jonathan L, Albert Avery B, Elfstrom Sarah, Forken Patricia, Blatt Steven D, Fremont Wanda P, Faraone Stephen V, Glatt Stephen J

Abstract excerpt

The Research Domain Criteria (RDoC) initiative was established by the US National Institute of Mental Health as a multilevel, disorder-agnostic framework for analysis of human psychopathology through designated domains and constructs, including the "Positive Valence Systems" domain focused on reward-related behavior. This study investigates the reward valuation subconstruct of "effort" and its association with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37953388
DOI: 10.1002/ajmg.b.32964
PMCID: PMC11076170

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