Article
Striatal response to reward anticipation: evidence for a systems-level intermediate phenotype for schizophrenia.
JAMA psychiatry - 1 May 2014
Grimm Oliver, Heinz Andreas, Walter Henrik, Kirsch Peter, Erk Susanne, Haddad Leila, Plichta Michael M, Romanczuk-Seiferth Nina, Pöhland Lydia, Mohnke Sebastian, Mühleisen Thomas W, Mattheisen Manuel, Witt Stephanie H, Schäfer Axel, Cichon Sven, Nöthen Markus, Rietschel Marcella, Tost Heike, Meyer-Lindenberg Andreas
Abstract excerpt
IMPORTANCE: Attenuated ventral striatal response during reward anticipation is a core feature of schizophrenia that is seen in prodromal, drug-naive, and chronic schizophrenic patients. Schizophrenia is highly heritable, raising the possibility that this phenotype is related to the genetic risk for the disorder. OBJECTIVE: To examine a large sample of healthy first-degree relatives of schizophrenic patients and...
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