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Article

Polygenic Risks for Depression and Neural Responses to Reward and Punishment in Young Adults.

Biological psychiatry. Cognitive neuroscience and neuroimaging - 1 Nov 2025

Chen Yu, Li Huey-Ting, Luo Xingguang, Li Guangfei, Ide Jaime S, Li Chiang-Shan R

Abstract excerpt

BACKGROUND: Extensive research has shown aberrant reward and punishment processing in people with depression. Genetic risks contribute to depression, but whether or how these risks of depression may affect behavioral and neural responses to reward and punishment remains unclear. METHODS: We curated the data of 879 young adults performing a gambling task during brain imaging from the Human Connectome Project....

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Identifiers

PMID: 40412620
DOI: 10.1016/j.bpsc.2025.05.008
PMCID: PMC12354074

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