Article
Envelope-specific B-cell populations in African green monkeys chronically infected with simian immunodeficiency virus.
Nature communications - 6 Jul 2016
Zhang Ruijun, Martinez David R, Nguyen Quang N, Pollara Justin, Arifin Trina, Stolarchuk Christina, Foulger Andrew, Amos Josh D, Parks Robert, Himes Jonathon E, Wang Minyue, Edwards Regina W, Trama Ashley M, Vandergrift Nathan, Colvin Lisa, Dewar Ken, Juretic Nikoleta, Wasserscheid Jessica, Ferrari Guido, Liao Hua-Xin, Permar Sallie R
Abstract excerpt
African green monkeys (AGMs) are natural primate hosts of simian immunodeficiency virus (SIV). Interestingly, features of the envelope-specific antibody responses in SIV-infected AGMs are distinct from that of HIV-infected humans and SIV-infected rhesus monkeys, including gp120-focused responses and rapid development of autologous neutralization. Yet, the lack of genetic tools to evaluate B-cell lineages hinders...
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