Article
Predominant envelope variable loop 2-specific and gp120-specific antibody-dependent cellular cytotoxicity antibody responses in acutely SIV-infected African green monkeys.
Retrovirology - 9 Mar 2018
Nguyen Quang N, Martinez David R, Himes Jonathon E, Whitney Edwards R, Han Qifeng, Kumar Amit, Mangan Riley, Nicely Nathan I, Xie Guanhua, Vandergrift Nathan, Shen Xiaoying, Pollara Justin, Permar Sallie R
Abstract excerpt
BACKGROUND: The initial envelope (Env)-specific antibody response in acutely HIV-1-infected individuals and simian immunodeficiency virus (SIV)-infected rhesus monkeys (RMs) is dominated by non-neutralizing antibodies targeting Env gp41. In contrast, natural primate SIV hosts, such as African green monkeys (AGMs), develop a predominant Env gp120-specific antibody response to SIV infection. However, the...
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