Distribution, persistence, and efficacy of adoptively transferred central and effector memory-derived autologous simian immunodeficiency virus-specific CD8+ T cell clones in rhesus macaques during acute infection.

doi:10.4049/jimmunol.0902410

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Article

Distribution, persistence, and efficacy of adoptively transferred central and effector memory-derived autologous simian immunodeficiency virus-specific CD8+ T cell clones in rhesus macaques during acute infection.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 2010

Minang Jacob T, Trivett Matthew T, Bolton Diane L, Trubey Charles M, Estes Jacob D, Li Yuan, Smedley Jeremy, Pung Rhonda, Rosati Margherita, Jalah Rashmi, Pavlakis George N, Felber Barbara K, Piatak Michael, Roederer Mario, Lifson Jeffrey D, Ott David E, Ohlen Claes

Abstract excerpt

Plasma viremia decreases coincident with the appearance of virus-specific CD8(+) T cells during acute HIV or SIV infection. This finding, along with demonstrations of viral mutational escape from CD8(+) T cell responses and transient increase in plasma viremia after depletion of CD8(+) T cells in SIV-infected monkeys strongly suggest a role for CD8(+) T cells in controlling HIV/SIV. However, direct quantitative...

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PMID: 19949091
DOI: 10.4049/jimmunol.0902410
PMCID: PMC2797560

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