Article
Genetic identity and biological phenotype of a transmitted/founder virus representative of nonpathogenic simian immunodeficiency virus infection in African green monkeys.
Journal of virology - 1 Dec 2010
Gnanadurai Clement Wesley, Pandrea Ivona, Parrish Nicholas F, Kraus Matthias H, Learn Gerald H, Salazar Maria G, Sauermann Ulrike, Töpfer Katharina, Gautam Rajeev, Münch Jan, Stahl-Hennig Christiane, Apetrei Christian, Hahn Beatrice H, Kirchhoff Frank
Abstract excerpt
Understanding the lack of disease progression in nonpathogenic simian immunodeficiency virus (SIV) infections is essential for deciphering the immunopathogenesis of human AIDS. Yet, in vivo studies have been hampered by a paucity of infectious molecular clones (IMCs) of SIV suitable to dissect the viral and host factors responsible for the nonpathogenic phenotype. Here, we describe the identification, cloning,...
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