Article
Fat Mass Reduction With Adipocyte Hypertrophy and Insulin Resistance in Heterozygous PPARγ Mutant Rats.
Diabetes - 1 Oct 2016
Gumbilai Valentino, Ebihara Ken, Aizawa-Abe Megumi, Ebihara Chihiro, Zhao Mingming, Yamamoto Yuji, Mashimo Tomoji, Hosoda Kiminori, Serikawa Tadao, Nakao Kazuwa
Abstract excerpt
Agonist-induced activation of peroxisome proliferator-activated receptor-γ (PPARγ) stimulates adipocyte differentiation and insulin sensitivity. Patients with heterozygous PPARγ dominant-negative mutation develop partial lipodystrophy and insulin resistance. Inconsistent with this evidence in humans, it was reported that heterozygous PPARγ knockout mice have increased insulin sensitivity and that mice with...
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