Article
A mouse model of conditional lipodystrophy.
Proceedings of the National Academy of Sciences of the United States of America - 16 Oct 2007
Kim Suyeon, Huang Li-Wen, Snow Kathy J, Ablamunits Vitaly, Hasham Muneer G, Young Timothy H, Paulk Angelique C, Richardson Joel E, Affourtit Jason P, Shalom-Barak Tali, Bult Carol J, Barak Yaacov
Abstract excerpt
Lipodystrophies are syndromes of adipose tissue degeneration associated with severe defects in lipid and glucose homeostasis. We report here the generation and analysis of Pparg(ldi), a targeted allele that confers conditional dominant lipodystrophy in mice. The Pparg(ldi) allele was generated by insertion of the Tet activator (tTA) and a tTA-regulated Flag-Pparg1 transgene into the Pparg gene. Unexpectedly, tTA...
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