Article
Genetic variations in peroxisome proliferator-activated receptor gamma expression affect blood pressure.
Proceedings of the National Academy of Sciences of the United States of America - 10 Nov 2009
Tsai Yau-Sheng, Xu Lonquan, Smithies Oliver, Maeda Nobuyo
Abstract excerpt
Metabolic syndrome, a clustering of conditions including obesity, insulin resistance, and hypertension, is a risk factor for cardiovascular morbidity and mortality. Because peroxisome proliferator-activated receptor gamma (PPARgamma) regulates adipocyte differentiation and lipid metabolism and is the molecular target of a class of insulin sensitizers, genetic variants that alter Pparg gene expression are...
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