Article
Transforming Growth Factor-β1 T869C Gene Polymorphism Is Associated with Acquired Sick Sinus Syndrome via Linking a Higher Serum Protein Level.
PloS one - 1 Jan 2016
Chen Jan-Yow, Liu Jiung-Hsiun, Wu Hong-Dar Isaac, Lin Kuo-Hung, Chang Kuan-Cheng, Liou Ying-Ming
Abstract excerpt
BACKGROUND: Familial sick sinus syndrome is associated with gene mutations and dysfunction of ion channels. In contrast, degenerative fibrosis of the sinus node tissue plays an important role in the pathogenesis of acquired sick sinus syndrome. There is a close relationship between transforming growth factor-β1 mediated cardiac fibrosis and acquired arrhythmia. It is of interest to examine whether transforming...
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