Article
Promoter polymorphism G-6A, which modulates angiotensinogen gene expression, is associated with non-familial sick sinus syndrome.
PloS one - 1 Jan 2012
Chen Jan-Yow, Liou Ying-Ming, Wu Hong-Dar Isaac, Lin Kuo-Hung, Chang Kuan-Cheng
Abstract excerpt
BACKGROUND: It is well known that familial sick sinus syndrome (SSS) is caused by functional alterations of ion channels and gap junction. Limited information is available on the mechanism of age-related non-familial SSS. Although evidence shows a close link between arrhythmia and the renin-angiotensin system (RAS), it remains to be determined whether the RAS is involved in the pathogenesis of non-familial SSS....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.