Phenotypes, accumulation, and functions of myeloid-derived suppressor cells and associated treatment strategies in cancer patients.

doi:10.1016/j.humimm.2014.09.025

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Article

Phenotypes, accumulation, and functions of myeloid-derived suppressor cells and associated treatment strategies in cancer patients.

Human immunology - 1 Nov 2014

Jiang Jingwei, Guo Weijian, Liang Xiaohua

Abstract excerpt

Myeloid-derived suppressor cells (MDSCs) comprise a group of heterogeneous and immature myeloid-derived cells. MDSCs accumulate in the blood, lymphoid organs, spleens and tumor tissues under different pathogenic conditions such as infection, trauma, hematosepsis, and especially oncogenesis. MDSCs can suppress both adaptive and innate immunities through multiple mechanisms. However, most of our knowledge of MDSCs...

Topics

Antigens, CD
Antineoplastic Agents
Cell Lineage
Disease Management
Gene Expression Regulation
Humans
Immunophenotyping
Myeloid Cells
Neoplasm Proteins
Neoplasms
Phenotype
Prognosis
Signal Transduction
Treatment Outcome

Source

Open in PubMed

Identifiers

PMID: 25305034
DOI: 10.1016/j.humimm.2014.09.025

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