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Article

Myeloid-Derived Suppressor Cells: Immune-Suppressive Cells That Impair Antitumor Immunity and Are Sculpted by Their Environment.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2018

Ostrand-Rosenberg Suzanne, Fenselau Catherine

Abstract excerpt

Myeloid-derived suppressor cells (MDSC) are a diverse population of immature myeloid cells that have potent immune-suppressive activity. Studies in both mice and humans have demonstrated that MDSC accumulate in most individuals with cancer, where they promote tumor progression, inhibit antitumor immunity, and are an obstacle to many cancer immunotherapies. As a result, there has been intense interest in...

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Identifiers

PMID: 29311384
DOI: 10.4049/jimmunol.1701019
PMCID: PMC5765878

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Source receipt: pubmed, retrieved 7 Sept 2026.

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