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Article

Plasticity of myeloid-derived suppressor cells in cancer.

Current opinion in immunology - 1 Apr 2018

Tcyganov Evgenii, Mastio Jerome, Chen Eric, Gabrilovich Dmitry I

Abstract excerpt

In recent years, myeloid-derived suppressor cells (MDSC) have emerged as one of the major inhibitors of immune effector cell function in cancer. MDSC represent a heterogeneous population of largely immature myeloid cells that are characterized by a pathological state of activation and display potent immune suppressive activity. Two major subsets of MDSC have been identified: monocytic (M-MDSC) and...

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Identifiers

PMID: 29547768
DOI: 10.1016/j.coi.2018.03.009
PMCID: PMC5943174

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