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Article

A Simplified Proteomics LC-MRM-MS Assay for Determination of apoE Genotypes in Plasma Samples.

Journal of proteome research - 5 Apr 2024

Qasrawi Deema O, Al-Ghabkari Abdulhameed, Khan Rania M, Petrotchenko Evgeniy V, Montero-Odasso Manuel, Borchers Christoph H

Abstract excerpt

Apolipoprotein E (apoE), a polymorphic plasma protein, plays a pivotal role in lipid transportation. The human apoE gene possesses three major alleles (ε2, ε3, and ε4), which differ by single amino acid (cysteine to arginine) substitutions. The ε4 allele represents the primary genetic risk factor for Alzheimer's disease (AD), whereas the ε2 allele protects against the disease. Knowledge of a patient's apoE...

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Identifiers

PMID: 38412507
DOI: 10.1021/acs.jproteome.3c00557
PMCID: PMC11002930

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