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Article

ATRA modulates mechanical activation of TGF-β by pancreatic stellate cells.

Scientific reports - 4 Jul 2016

Sarper Muge, Cortes Ernesto, Lieberthal Tyler J, Del Río Hernández Armando

Abstract excerpt

The hallmark of pancreatic ductal adenocarcinoma (PDAC) is abundant desmoplasia, which is orchestrated by pancreatic stellate cells (PSCs) and accounts for the majority of the stroma surrounding the tumour. Healthy PSCs are quiescent, but upon activation during disease progression, they adopt a myofibroblast-contractile phenotype and secrete and concomitantly reorganise the stiff extracellular matrix (ECM)....

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Identifiers

PMID: 27375161
DOI: 10.1038/srep27639
PMCID: PMC4931506

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