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Article

Fate-determining mechanisms in epithelial–myofibroblast transition: major inhibitory role for Smad3

1 Feb 2010

Abstract excerpt

Epithelial-myofibroblast (MF) transition (EMyT) is a critical process in organ fibrosis, leading to alpha-smooth muscle actin (SMA) expression in the epithelium. The mechanism underlying the activation of this myogenic program is unknown. We have shown previously that both injury to intercellular contacts and transforming growth factor beta (TGF-beta) are indispensable for SMA expression (two-hit model) and that...

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PMID: 20123992
DOI: 10.1083/jcb.200906155

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