Article

Retinoid acid receptor β mechanically regulates the activity of pancreatic cancer cells

2022-08-13

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is the most common and lethal form of pancreatic cancer, characterised by stromal remodelling, elevated matrix stiffness and high metastatic rate. Retinoids, compounds derived from vitamin A, have a history of clinical use in cancer for their anti-proliferative and differentiation effects, and more recently have been explored as anti-stromal therapies in PDAC for their abili...

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Literature Corpus work: ddf15026-3903-5008-b7cb-ecff444100d6
DOI: 10.1101/2022.08.10.503236

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