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Article

Pancreatic stellate cells activated by mutant KRAS-mediated PAI-1 upregulation foster pancreatic cancer progression via IL-8.

Theranostics - 1 Jan 2019

Wang Hao-Chen, Lin Yung-Lun, Hsu Ching-Cheng, Chao Ying-Jui, Hou Ya-Chin, Chiu Tai-Jan, Huang Po-Hsien, Tang Ming-Jer, Chen Li-Tzong, Shan Yan-Shen

Abstract excerpt

Background: The dense fibrotic stroma enveloping pancreatic tumors is a major cause of drug resistance. Pancreatic stellate cells (PSCs) in the stroma can be activated to induce intra-tumor fibrosis and worsen patient survival; however, the molecular basics for the regulation of PSC activation remains unclear. Methods: The in vitro coculture system was used to study cancer cell-PSC interactions. Atomic force...

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Identifiers

PMID: 31695760
DOI: 10.7150/thno.36830
PMCID: PMC6831292

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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