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Article

Pancreatic stellate cells radioprotect pancreatic cancer cells through β1-integrin signaling.

Cancer research - 15 May 2011

Mantoni Tine S, Lunardi Serena, Al-Assar Osama, Masamune Atsushi, Brunner Thomas B

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a strong desmoplastic reaction where the stromal compartment often accounts for more than half of the tumor volume. Pancreatic stellate cells (PSC) are a central mediator of desmoplasia. There is increasing evidence that desmoplasia is contributing to the poor therapeutic response of PDAC. We show that PSCs promote radioprotection and stimulate...

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Identifiers

PMID: 21558392
DOI: 10.1158/0008-5472.CAN-10-1633
PMCID: PMC3097171

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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