Article
The hard problem: Mechanotransduction perpetuates the myofibroblast phenotype in scleroderma fibrosis.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society - 1 Jul 2021
Leask Andrew
Abstract excerpt
The effector cells ultimately responsible for fibrosis are myofibroblasts. In the fibrotic autoimmune connective tissue disease scleroderma, myofibroblasts are autonomously activated, and retain their phenotype upon culturing. Since the 1990s, researchers have exploited this fact to use scleroderma fibroblasts as a model system to uncover the fundamental mechanisms underlying myofibroblast persistence in fibrotic...
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