Article
Exome chip analyses identify genes affecting mortality after HLA-matched unrelated-donor blood and marrow transplantation.
Blood - 31 May 2018
Zhu Qianqian, Yan Li, Liu Qian, Zhang Chi, Wei Lei, Hu Qiang, Preus Leah, Clay-Gilmour Alyssa I, Onel Kenan, Stram Daniel O, Pooler Loreall, Sheng Xin, Haiman Christopher A, Zhu Xiaochun, Spellman Stephen R, Pasquini Marcelo, McCarthy Philip L, Liu Song, Hahn Theresa, Sucheston-Campbell Lara E
Abstract excerpt
Although survival outcomes have significantly improved, up to 40% of patients die within 1 year of HLA-matched unrelated-donor blood and marrow transplantation (BMT). To identify non-HLA genetic contributors to mortality after BMT, we performed the first exome-wide association study in the DISCOVeRY-BMT cohorts using the Illumina HumanExome BeadChip. This study includes 2473 patients with acute myeloid leukemia,...
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