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Article

Donor polymorphisms of toll-like receptor 4 associated with graft failure in liver transplant recipients.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society - 1 Dec 2012

Oetting William S, Guan Weihua, Schladt David P, Leduc Robert E, Jacobson Pamala A, Matas Arthur J, Chinnakotla Srinath, Schröppel Bernd, Murphy Barbara T, Israni Ajay K

Abstract excerpt

There have been many reports showing significant associations between recipient genetic variants and allograft outcomes, including acute rejection and graft failure, but less is known about the contribution of the donor genotype. We analyzed 37 single-nucleotide polymorphisms (SNPs) within the toll-like receptor 4 (TLR4) gene from deceased donor liver allografts transplanted into 738 recipients to determine their...

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Identifiers

PMID: 22987288
DOI: 10.1002/lt.23549
PMCID: PMC3518641

Genes

TLR4

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