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Article

Arg188 drives RhoC membrane binding.

Small GTPases - 3 Apr 2017

Patel Aditi, Williams-Perez Sophia, Peyton Nicole, Reicks Amy, Buzick Justin, Farley Janean, Shirar Sarah, Ellerbroek Shawn M

Abstract excerpt

RhoA and RhoC GTPases are 92% identical but demonstrate unique regulation and function. Phosphorylation of Ser188 has widely been reported to inhibit RhoA activity. RhoC possesses Arg188 in place of Ser188 but retains a canonical upstream PKA recognition sequence. We report here that RhoC-R188S was a PKA substrate in vitro and exhibited less GTP loading compared to wild-type RhoC when expressed in cells....

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Identifiers

PMID: 27355867
DOI: 10.1080/21541248.2016.1205334
PMCID: PMC5464120

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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