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Article

Identification of an inhibitory domain in GTPase-activating protein p190RhoGAP responsible for masking its functional GAP domain.

The Journal of biological chemistry - 1 Jan 2023

Héraud Capucine, Pinault Mathilde, Neaud Véronique, Saltel Frédéric, Lagrée Valérie, Moreau Violaine

Abstract excerpt

The GTPase-activating protein (GAP) p190RhoGAP (p190A) is encoded by ARHGAP35 which is found mutated in cancers. p190A is a negative regulator of the GTPase RhoA in cells and must be targeted to RhoA-dependent actin-based structures to fulfill its roles. We previously identified a functional region of p190A called the PLS (protrusion localization sequence) required for localization of p190A to lamellipodia but...

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Identifiers

PMID: 36516886
DOI: 10.1016/j.jbc.2022.102792
PMCID: PMC9840978

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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