Article
Impact of Genetic Variation in MicroRNA-binding Site on Susceptibility to Colorectal Cancer.
Anticancer research - 1 Jul 2016
Kang Byung Woog, Jeon Hyo-Sung, Chae Yee Soo, Lee Soo Jung, Park Jun Seok, Choi Gyu Seog, Kim Jong Gwang
Abstract excerpt
The present study analyzed single nucleotide polymorphisms (SNPs) located at putative microRNA(miRNA)-binding sites of the 3'-untranslated region (UTR) in different genes and investigated their impact on the susceptibility to colorectal cancer (CRC). Ninety-two SNPs were selected using an in silico analysis of 3'-UTR SNPs in an SNP database and their miRNA binding efficiency was calculated using several miRNA...
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