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Article

Homology directed repair is unaffected by the absence of siRNAs in Drosophila melanogaster.

Nucleic acids research - 30 Sept 2016

Schmidts Ines, Böttcher Romy, Mirkovic-Hösle Milijana, Förstemann Klaus

Abstract excerpt

Small interfering RNAs (siRNAs) defend the organism against harmful transcripts from exogenous (e.g. viral) or endogenous (e.g. transposons) sources. Recent publications describe the production of siRNAs induced by DNA double-strand breaks (DSB) in Neurospora crassa, Arabidopsis thaliana, Drosophila melanogaster and human cells, which suggests a conserved function. A current hypothesis is that break-induced small...

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Identifiers

PMID: 27353331
DOI: 10.1093/nar/gkw570
PMCID: PMC5041469

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Source receipt: pubmed, retrieved 7 Sept 2026.

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