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Article

Dicer is essential for formation of the heterochromatin structure in vertebrate cells.

Nature cell biology - 1 Aug 2004

Fukagawa Tatsuo, Nogami Masahiro, Yoshikawa Mitsuko, Ikeno Masashi, Okazaki Tuneko, Takami Yasunari, Nakayama Tatsuo, Oshimura Mitsuo

Abstract excerpt

RNA interference is an evolutionarily conserved gene-silencing pathway in which the nuclease Dicer cleaves double-stranded RNA into small interfering RNAs. The biological function of the RNAi-related pathway in vertebrate cells is not fully understood. Here, we report the generation of a conditional loss-of-function Dicer mutant in a chicken-human hybrid DT40 cell line that contains human chromosome 21. We show...

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Identifiers

PMID: 15247924
DOI: 10.1038/ncb1155

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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