Article
Small RNA-mediated repair of UV-induced DNA lesions by the DNA DAMAGE-BINDING PROTEIN 2 and ARGONAUTE 1.
Proceedings of the National Academy of Sciences of the United States of America - 4 Apr 2017
Schalk Catherine, Cognat Valérie, Graindorge Stéfanie, Vincent Timothée, Voinnet Olivier, Molinier Jean
Abstract excerpt
As photosynthetic organisms, plants need to prevent irreversible UV-induced DNA lesions. Through an unbiased, genome-wide approach, we have uncovered a previously unrecognized interplay between Global Genome Repair and small interfering RNAs (siRNAs) in the recognition of DNA photoproducts, prevalently in intergenic regions. Genetic and biochemical approaches indicate that, upon UV irradiation, the DNA...
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