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Article

Dicer's helicase domain discriminates dsRNA termini to promote an altered reaction mode.

Molecular cell - 4 Mar 2011

Welker Noah C, Maity Tuhin S, Ye Xuecheng, Aruscavage P Joseph, Krauchuk Ammie A, Liu Qinghua, Bass Brenda L

Abstract excerpt

The role of Dicer's helicase domain is enigmatic, but in vivo it is required for processing certain endogenous siRNA, but not miRNA. By using Caenorhabditis elegans extracts or purified Drosophila Dicer-2 we compared activities of wild-type enzymes and those containing mutations in the helicase domain. We found the helicase domain was essential for cleaving dsRNA with blunt or 5'-overhanging termini, but not...

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Identifiers

PMID: 21362554
DOI: 10.1016/j.molcel.2011.02.005
PMCID: PMC3061311

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