Article
Redundancy of the two dicer genes in transgene-induced posttranscriptional gene silencing in Neurospora crassa.
Molecular and cellular biology - 1 Mar 2004
Catalanotto Caterina, Pallotta Massimiliano, ReFalo Paul, Sachs Matthew S, Vayssie Laurence, Macino Giuseppe, Cogoni Carlo
Abstract excerpt
RNA interference (RNAi) in animals, cosuppression in plants, and quelling in fungi are homology-dependent gene silencing mechanisms in which the introduction of either double-stranded RNA (dsRNA) or transgenes induces sequence-specific mRNA degradation. These phenomena share a common genetic and mechanistic basis. The accumulation of short interfering RNA (siRNA) molecules that guide sequence-specific mRNA...
Topics
- Base Sequence
- DNA, Fungal
- Fungal Proteins
- Gene Deletion
- Genes, Fungal
- Mutation
- Neurospora crassa
- RNA Interference
- RNA, Double-Stranded
- RNA, Fungal
- RNA, Small Interfering
- Ribonuclease III