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CRISPR screening using an expanded toolkit of autophagy reporters identifies TMEM41B as a novel autophagy factor

1 Apr 2019

Abstract excerpt

The power of forward genetics in yeast is the foundation on which the field of autophagy research firmly stands. Complementary work on autophagy in higher eukaryotes has revealed both the deep conservation of this process, as well as novel mechanisms by which autophagy is regulated in the context of development, immunity, and neuronal homeostasis. The recent emergence of new clustered regularly interspaced...

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PMID: 30933966
DOI: 10.1371/journal.pbio.2007044

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