Article

Genome-wide synthetic lethal CRISPR screen identifies <i>FIS1</i> as a genetic interactor of ALS-linked <i>C9ORF72</i>

2019-09-21

Abstract excerpt

Mutations in the C9ORF72 gene are the most common cause of amyotrophic lateral sclerosis (ALS). Both toxic gain of function and loss of function pathogenic mechanisms have been proposed. Accruing evidence from mouse knockout studies point to a role for C9ORF72 as a regulator of immune function. To provide further insight into its cellular function, we performed a genome-wide synthetic lethal CRISPR screen in huma...

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Literature Corpus work: ce2a508f-6192-5393-bdeb-336ca398db82
DOI: 10.1101/778118

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Genome-wide synthetic lethal CRISPR screen identifies <i>FIS1</i> as a genetic interactor of ALS-linked <i>C9ORF72</i>DOI 10.1101/778118Read

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