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Article

Mutations of the X region of hepatitis B virus and their clinical implications.

Pathology international - 1 Apr 1997

Uchida T, Saitoh T, Shinzawa H

Abstract excerpt

Nucleotide (nt) sequences of the X region of more than 130 hepatitis B virus (HBV) isolates were determined and derived from patients with a variety of clinical features. Correlation of nt substitutions with clinicopathological characteristics was attempted. The X region (465nt) is crucial for the replication and expression of HBV because the X protein transactivates the HBV genes and this region contains the...

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PMID: 9103208
DOI: 10.1111/j.1440-1827.1997.tb04479.x

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