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Hepatitis B virus X protein-mediated non-coding RNA aberrations in the development of human hepatocellular carcinoma

10 Feb 2017

Abstract excerpt

Hepatitis B virus (HBV) has an important role in the development of human hepatocellular carcinoma (HCC). Accumulated evidence has shown that HBV-encoded X protein (HBx) can induce both genetic alterations in tumor suppressor genes and oncogenes, as well as epigenetic aberrations in HCC pathogens. Non-coding RNAs (ncRNAs) mainly include microRNAs and long non-coding RNAs (lncRNAs). Although ncRNAs cannot code...

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PMID: 28186085
DOI: 10.1038/emm.2016.177

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