Article
Specific localization of nesprin-1-α2, the short isoform of nesprin-1 with a KASH domain, in developing, fetal and regenerating muscle, using a new monoclonal antibody.
BMC cell biology - 27 Jun 2016
Holt Ian, Duong Nguyen Thuy, Zhang Qiuping, Lam Le Thanh, Sewry Caroline A, Mamchaoui Kamel, Shanahan Catherine M, Morris Glenn E
Abstract excerpt
BACKGROUND: Nesprin-1-giant (1008kD) is a protein of the outer nuclear membrane that links nuclei to the actin cytoskeleton via amino-terminal calponin homology domains. The short nesprin-1 isoform, nesprin-1-α2, is present only in skeletal and cardiac muscle and several pathogenic mutations occur within it, but the functions of this short isoform without calponin homology domains are unclear. The aim of this...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.