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Article

Depletion of Nesprin-2 is associated with an embryonic lethal phenotype in mice.

Nucleus (Austin, Tex.) - 1 Jan 2018

Mroß Carmen, Marko Marija, Munck Martina, Glöckner Gernot, Motameny Susanne, Altmüller Janine, Noegel Angelika A, Eichinger Ludwig, Peche Vivek S, Neumann Sascha

Abstract excerpt

Nesprin-2 is a nuclear envelope component and provides a link between cytoskeletal components of the cytoplasm and the nucleoplasm. Several isoforms are generated from its gene Syne2. Loss of the largest isoform Nesprin-2 Giant in mice is associated with a skin phenotype and altered wound healing, loss of C-terminal isoforms in mice leads to cardiomyopathies and neurological defects. Here we attempted to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30220251
DOI: 10.1080/19491034.2018.1523664
PMCID: PMC6244730

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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