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Article

Probing chromatin landscape reveals roles of endocardial TBX20 in septation.

The Journal of clinical investigation - 1 Aug 2016

Boogerd Cornelis J, Aneas Ivy, Sakabe Noboru, Dirschinger Ralph J, Cheng Quen J, Zhou Bin, Chen Ju, Nobrega Marcelo A, Evans Sylvia M

Abstract excerpt

Mutations in the T-box transcription factor TBX20 are associated with multiple forms of congenital heart defects, including cardiac septal abnormalities, but our understanding of the contributions of endocardial TBX20 to heart development remains incomplete. Here, we investigated how TBX20 interacts with endocardial gene networks to drive the mesenchymal and myocardial movements that are essential for outflow...

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Source

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Identifiers

PMID: 27348591
DOI: 10.1172/JCI85350
PMCID: PMC4966318

Genes

TBX20

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Probing chromatin landscape reveals roles of endocardial TBX20 in septation.PMID 27348591Read ↗

Tbx20 acts upstream of Wnt signaling to regulate endocardial cushion formation and valve remodeling during mouse cardiogenesisSemantic proximity Read ↗

Mutations in cardiac T-box factor gene TBX20 are associated with diverse cardiac pathologies, including defects of septation and valvulogenesis and cardiomyopathy.Semantic proximity Read ↗

Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart.Semantic proximity Read ↗

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