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Article

A Large Permissive Regulatory Domain Exclusively Controls Tbx3 Expression in the Cardiac Conduction System

25 Jun 2014

Abstract excerpt

RATIONALE: The evolutionary conserved Tbx3/Tbx5 gene cluster encodes T-box transcription factors that play crucial roles in the development and homeostasis of the cardiac conduction system in human and mouse. Both genes are expressed in overlapping patterns and function in strictly tissue-specific and dose-dependent manners, yet, their regulation is poorly understood. OBJECTIVE: To analyze the mechanism...

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PMID: 24963028
DOI: 10.1161/circresaha.115.303591

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A Large Permissive Regulatory Domain Exclusively Controls Tbx3 Expression in the Cardiac Conduction SystemPMID 24963028Read ↗

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