Article
Characterization of TBX20 in human hearts and its regulation by TFAP2.
Journal of cellular biochemistry - 1 Jun 2008
Hammer Stefanie, Toenjes Martje, Lange Martin, Fischer Jenny J, Dunkel Ilona, Mebus Siegrun, Grimm Christina H, Hetzer Roland, Berger Felix, Sperling Silke
Abstract excerpt
The T-box family of transcription factors has been shown to have major impact on human development and disease. In animal studies Tbx20 is essential for the development of the atrioventricular channel, the outflow tract and valves, suggesting its potential causative role for the development of Te...
Topics
- 5' Untranslated Regions
- Alternative Splicing
- Animals
- Biopsy
- DNA Mutational Analysis
- Gene Expression Regulation
- Heart
- Heart Diseases
- Humans
- Mice
- Mutation
- Myocardium
- T-Box Domain Proteins
- Transcription Factor AP-2