Article
Activation of tyrosine kinase c-Abl contributes to α-synuclein-induced neurodegeneration.
The Journal of clinical investigation - 1 Aug 2016
Brahmachari Saurav, Ge Preston, Lee Su Hyun, Kim Donghoon, Karuppagounder Senthilkumar S, Kumar Manoj, Mao Xiaobo, Shin Joo Ho, Lee Yunjong, Pletnikova Olga, Troncoso Juan C, Dawson Valina L, Dawson Ted M, Ko Han Seok
Abstract excerpt
Aggregation of α-synuclein contributes to the formation of Lewy bodies and neurites, the pathologic hallmarks of Parkinson disease (PD) and α-synucleinopathies. Although a number of human mutations have been identified in familial PD, the mechanisms that promote α-synuclein accumulation and toxicity are poorly understood. Here, we report that hyperactivity of the nonreceptor tyrosine kinase c-Abl critically...
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