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Article

A calcineurin- and NFAT-dependent pathway is involved in α-synuclein-induced degeneration of midbrain dopaminergic neurons.

Human molecular genetics - 15 Dec 2014

Luo Jing, Sun Lixin, Lin Xian, Liu Guoxiang, Yu Jia, Parisiadou Loukia, Xie Chengsong, Ding Jinhui, Cai Huaibin

Abstract excerpt

Parkinson's disease (PD), the most common degenerative movement disorder, is caused by a preferential loss of midbrain dopaminergic (mDA) neurons. Both α-synuclein (α-syn) missense and multiplication mutations have been linked to PD. However, the underlying intracellular signalling transduction pathways of α-syn-mediated mDA neurodegeneration remain elusive. Here, we show that transgenic expression of PD-related...

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Identifiers

PMID: 25051958
DOI: 10.1093/hmg/ddu377
PMCID: PMC4240205

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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