Article

Knockout of Rab27b exacerbates neuropathology in alpha-synuclein mouse models

2025-12-22

Abstract excerpt

<h4>ABSTRACT</h4> Parkinson’s Disease (PD) and other synucleinopathies are characterized by the formation of inclusions comprised of alpha-synuclein (αsyn) among other proteins, but the mechanisms by which these inclusions form and cause toxicity are not well understood. We have previously reported that the small GTPase Rab27b modulates autophagic-lysosomal function in neurons and supports lysosomal degradation o...

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Literature Corpus work: 69b562b8-608d-54ab-a7c0-77f8a25b4cfa
DOI: 10.64898/2025.12.19.695485

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