Ages at menarche- and menopause-related genetic variants in relation to terminal duct lobular unit involution in normal breast tissue.

doi:10.1007/s10549-016-3859-z

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Ages at menarche- and menopause-related genetic variants in relation to terminal duct lobular unit involution in normal breast tissue.

Breast cancer research and treatment - 1 Jul 2016

Oh Hannah, Bodelon Clara, Palakal Maya, Chatterjee Nilanjan, Sherman Mark E, Linville Laura, Geller Berta M, Vacek Pamela M, Weaver Donald L, Chicoine Rachael E, Papathomas Daphne, Patel Deesha A, Xiang Jackie, Clare Susan E, Visscher Daniel W, Mies Carolyn, Hewitt Stephen M, Brinton Louise A, Storniolo Anna Maria V, He Chunyan, Garcia-Closas Montserrat, Chanock Stephen J, Gierach Gretchen L, Figueroa Jonine D

Abstract excerpt

Reduced levels of terminal duct lobular unit (TDLU) involution, as reflected by higher numbers of TDLUs and acini per TDLU, have been associated with higher breast cancer risk. Younger age at menarche and older age at menopause have been previously related to lower levels of TDLU involution. To determine a possible genetic link, we examined whether single-nucleotide polymorphisms (SNPs) previously established in...

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PMID: 27342457
DOI: 10.1007/s10549-016-3859-z
PMCID: PMC5144736

Genes

EXO1
GAB2
RXRG

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